Celiprolol

Celiprolol is a drug used to treat high blood pressure and coronary artery disease. The drug belongs to the group of beta blockers. It is mostly not used as a single drug, but in combination with others. Various side effects or interactions can occur with Celiprolol. The drug must always be used in consultation with the attending physician.

What is Celiprolol?

Celiprolol is a drug that is used to treat what is called essential high blood pressure that has no organic cause. Celiprolol is also used to treat coronary artery disease and to treat stable angina pectoris.

Celiprolol in particular is a ß-receptor blocker. The drug acts as an antagonist on the ß1 adrenoceptors and as a partial agonist on the ß2 adrenoceptors.

The drug Celiprolol is broken down by the body through the kidneys. It is therefore important to clarify whether renal insufficiency is present before prescribing, as celiprolol must not be administered in this case. Celiprolol is available in the form of film-coated tablets.

Pharmacological effect

Celiprolol causes vasodilation of the peripheral blood vessels. This property of the drug is not only used to improve blood circulation. The drug Celiprolol is also well suited to be combined with other drugs to lower high blood pressure. In this way, side effects can be prevented with other drugs used, since the administration of Celiprolol in turn can reduce the dose of these drugs.

The supplementary drugs include vasodilitators, thiazide-like dehydrating agents, alpha blockers or calcium channel blockers of the nifedipine type. Celiprolol itself, in turn, can be combined well with long-term nitrates.

Medical application & use

The healing effect of Celiprolol for high blood pressure or circulatory disorders in the case of coronary heart disease results as follows: The beta-1 receptors in the body are naturally activated by the messenger substances noradrenaline and adrenaline. The effect of these natural messenger substances is suppressed by Celiprolol because this drug displaces these messenger substances and instead binds itself to these receptors.

In this way, both the number of heartbeats and the heartbeat volume are reduced. The blood pressure is already lowered by this mode of action. Celiprolol also causes the kidneys to release the hormone renin. This also causes a further reduction in blood pressure.

In addition, Celiprolol reduces the stress activity of the heart by slowing down the transmission of electrical impulses to the heart's conduction system. Celiprolol also has a beneficial effect on the composition of blood lipids by keeping cholesterol levels low.

Risks & side effects

While the drug Celiprolol is a very powerful drug, it can also have a number of side effects and interactions. It is therefore very important to have your blood lipid values, blood sugar values ​​and liver values ​​checked regularly by a doctor.

Anyone who does sport should find out beforehand whether Celiprolol is on the doping list in this sport. Because this is the case with some sports, for example fencing, some aviation sports, alpine skiing or shooting.

Patients with angina pectoris should have their heart rate checked regularly while taking Celiprolol. All high blood pressure patients need to have their blood pressure checked regularly. In the event of anesthesia, it is very important to inform the anesthetist that Celiprolol is being taken.

Likewise, people with hypoglycaemia or an overactive thyroid must undergo regular thorough examinations when taking the drug. If you have a tendency to psoriasis, Celiprolol is often not tolerated. The drug often reduces the amount of tear fluid, which can cause problems for people who wear contact lenses.

Reactivity is also reduced, especially in combination with alcohol. This is particularly important when driving a car or operating machines. Other side effects are worsening asthma, diabetes, depression, muscle cramps, allergic skin reactions, visual disturbances, deterioration in cardiac output, diarrhea, constipation, nausea, vomiting and much more.

The possible side effects on the package insert should be taken into account and discussed with the doctor if they occur. If Celiprolol has to be discontinued again because of the side effects, it must be tapered over a period of one to two weeks, as otherwise the blood pressure can rise to dangerous levels.