Domperidone

The Domperidone is a remedy used to treat acute and chronic gastric pain and the associated symptoms of vomiting and nausea. It is mainly used by travel sick and pregnant women.

What is domperidone?

Domperidone is a remedy for the treatment of acute and chronic pain in the stomach and the associated symptoms of vomiting and nausea.

As Domperidone is a medical product used to prevent various symptoms that can arise from the gastrointestinal tract. In particular, nausea, vomiting, diarrhea and all types of abdominal pain are included.

The feeling of fullness can also be treated with the remedy. In addition to acute use in such ailments, therapy for protracted forms of illness is also conceivable. Domperidone is therefore an anti-emetic - a preparation that is supposed to inhibit nausea and nausea.

Domperidone is used, for example, when traveling, when the movements of the means of transport trigger such symptoms. But also in connection with pregnancy, medical measures or as part of a surgical procedure, the mentioned clinical pictures can occur again and again, which are suppressed by domperidone.

Pharmacological effect

Generally that should Domperidone act as an antagonist of dopamine. This is a neurotransmitter and thus a messenger substance that triggers irritation in the nerve cells.

It is crucial that this messenger can connect to the so-called dopamine receptor in the nervous system and thus trigger nausea and vomiting. This is where domperidone comes in, blocking the aforementioned pathway of dopamine and preventing its access to the receptor. However, this does not necessarily rule out the symptoms.

The preparation stimulates the activity of the gastrointestinal area, which can initially lead to an increased perception of dizziness and other accompanying circumstances. In this respect, domperidone is already being replaced by alternative anti-emetics in severe illnesses. But where a quick emptying of the stomach is desired, the agent can be used for treatment.

The emergencies of poisoning or incompatible foods would be conceivable. It also proves to be disadvantageous that the mode of action of domperidone has still not been clearly clarified and precisely the cause of the increased gastric activity is still puzzled.

Medical application & use

The Domperidone is therefore always used where acute complaints of the intestine and stomach become noticeable. For example, in traffic in an airplane or on a ship, where the turbulence of the journey and the nervousness of the moment lead to a low level of nausea. The follow-up care of a surgical procedure can also lead to inconvenience, which can lead to vomiting and considerable dizziness.

Here, too, it is necessary to use domperidone for acute symptom relief. In contrast, protracted and even chronic clinical pictures can also be remedied. These can be triggered by pregnancy, for example. The morning sickness is known to many affected women and is reduced to a tolerable level by the domperidone. If the manifestations cannot be cured, the remedy is usually replaced by stronger preparations.

In such cases, it must be assumed that a switch to alternative products or even medical intervention is necessary in order to get to the bottom of the actual ailment. In some patients there are even organic reasons why domperidone cannot gain access to the dopamine receptor and develop its blocking effect there.

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➔ Medicines against nausea and vomiting

Risks & side effects

Despite its tendency to rule out diseases in the gastrointestinal area, it will Domperidone in a few cases, increase this with the beginning of the intake. Usually this is a temporary side effect.

However, the remedy should only be used for a limited period of time, as long-term use of domperidone can cause fertility disorders in some patients, which can lead to impotence. In addition, an increase in the prolactin level can often be detected, especially in pregnant women, which is often associated with changes in the flow of milk from the breast.

A negative effect of domperidone on the heart has also been scientifically confirmed. In particular, higher doses of the agent can lead to cardiac arrhythmias and even cause cardiac death. The domperidone may therefore only be used under medical supervision.